Derek Carr (Oak @ Bal) – Carr had the second-best fantasy performance of his 25 game professional career against the Ravens last year. It was a big volume game as he completed 30 of 46 passes for 351 yards and 3 TDs and 1 INT for 31.9 FP.
Andrew Luck (Ind @ Jac) – Luck didn’t face the Jaguars in 2015 due to injury but he averaged 28.8 FPG against them in two starts in 2014. He combined for more than 300 yards of offense (passing and rushing) in each of those games and tossed 4 TDs the last time he played Jacksonville on the road.
Joe Flacco (Bal vs. Oak) – It was a Flacco/Carr shootout in Week 2 of 2015 as each QB threw for 350+ and multiple TDs. Flacco finished the day completing 71% of his passes for 384 yards and 2 TDs along with a pick (27.4 FP).
Matthew Stafford (Det @ Chi) – Stafford owned the Lions last year averaging 34.0 FPG against them in two starts. He posted stat lines of 405/4/1 and 298/3/0 in those two games and completed 68% of his passes overall.
Blake Bortles (Jac vs. Ind) – Bortles averaged 27.1 FPG in his two games against the Colts last season accounting for a total of 5 TDs (4 passing, 1 rushing) with 0 INTs. He posted 32.2 FP at home against them in their most recent meeting throwing for 250/3/0 and rushing for 4/17/1.
DeMarco Murray (Ten @ Hou) – Murray was a workhorse against the Texans when was a Cowboy in Week 5 2014 carrying 31 times for 136 yards and adding 6/56 receiving for 25.2 FP on the day.
Jerick McKinnon (Min vs. NYG) – McKinnon rolled up 97 total yards and 2 TDs on just 9 touches against the Giants in Week 16 of last season (23.7 FP)
Lamar Miller (Hou vs. Ten) – Miller knifed through the Titans’ defense for 113 rushing yards and a TD on 19 carries (5.9 YPC) in Week 6 last year (19.8 FP).
LeSean McCoy (Buf @ NE) – McCoy averaged 19.5 FPG in two games against New England last year as he gained more than 110 total yards in both meetings. Most recently in Week 11 in 2015 at New England he carried 20 times for 82 yards and a TD and added 41 yards on 6 catches for a total of 24.3 FP.
Latavius Murray (Oak @ Bal) – Murray had a strong game for fantasy against the Ravens in Week 2 of last season gaining 87 total yards on 18 touches and finding the end zone en route to 17.7 FP.
Rashad Jennings (NYG @ Min) – Jennings racked up 136 total yards on 16 touches last year against the Vikings (15.6 FP).
James White (NE vs. Buf) – White scored a pair of TDs in his last game against the Bills back in Week 11 of last season on just 4 touches. He rushed for one and caught the other and also totaled 46 yards (18.6 FP).
DeAndre Hopkins (Hou vs. Ten) – Hopkins has been a beast against the Titans averaging 30.1 FPG over his last three games in this series. He’s caught at least 7 balls for at least 90 yards and at least 1 TD in all three games averaging a ridiculous 8/150/1.3.
Mohamed Sanu (Atl vs. Car) – Sanu wore out the Panthers when he was a Bengal back in Week 6 2014. He caught 10 of his 14 targets for 120 yards and a TD (28.0 FP).
Julian Edelman (NE vs. Buf) – Edelman is averaging 26.5 FPG against the Bills over the last two seasons. Most recently in Week 2 of last season he was targeted 19 times, catching 11 for 97 yards and a pair of TDs (33.9 FP).
Michael Crabtree (Oak @ Bal) – It was all systems go for the Raiders offense last year against the Ravens and Crabtree certainly did his part by posting a 9/111/1 stat line on 16 targets (26.1 FP).
Amari Cooper (Oak @ Bal) – Both Cooper and Crabtree went over 100 yards and scored in their Week 2 tilt with the Ravens last year. Cooper scored 23.9 FP on a 7/109/1 stat line.
Alshon Jeffery (Chi vs. Det) – Alshon loves playing against the Lions as he’s averaging 25.3 FPG against them since 2014. He’s caught at least 6 passes for at least 70 yards and at least 1 TD in all three of the games in that span. Going back even further, Jeffery has scored more than 19.0 FP in five straight games against the Lions.
Allen Hurns (Jac vs. Ind) – Hurns knocked it out of the park in both games against the Colts last year topping 100 yards and scoring in each game (24.1 FPG).
Julio Jones (Atl vs. Car) – After struggling a bit in this matchup in 2014, Julio came through with two worthy fantasy performances against the Panthers last year averaging 24.3 FPG. Most recently in Week 16 2015 he beat them for 178 yards and a TD on 9 catches (32.8 FP).
Steve Smith (Bal vs. Oak) – It was a shootout for the Ravens against the Raiders in their 2015 meeting and Smith was targeted a whopping 16 times catching 10 of them for 150 yards (25.0 FP).
Antonio Brown (Pit vs. KC) – While Big Ben’s numbers haven’t been particularly good against the Chiefs, a lot of his production has gone to Antonio Brown as he is averaging 19.6 FPG in his last two games in this matchup posting stat lines of 6/124/0 last year and 7/72/1 in 2014.
T.Y. Hilton (Ind @ Jac) – Hilton is averaging 5 catches for 100 yards over his last four meetings with the Jaguars. He’s only scored once in those four games but he’s still averaging 16.9 FPG against them.
Robert Woods (Buf @ NE) – Here’s something to consider if Sammy Watkins is out this week. Woods has scored in three of his last four games against the Patriots and is averaging 14.5 FPG against them during that span.
Tavon Austin (LA @ Ari) – Austin’s fantasy numbers have been very up and down over the course of his career so far and he only managed 4.8 FP against the Cardinals in Week 13 2015. However, one of his biggest games ever came the last time he played at Arizona in Week 4 of last season. He racked up 29.6 FP against them catching 6 balls for 96 yards and 2 TDs and rushing for another 20 yards.
Chris Conley (KC @ Pit) – For what it’s worth, Conley had his most productive game of his young NFL career against the Steelers last year. He caught 6 of his 7 targets (including 3 in the red zone) for 63 yards and his only career TD to this point (18.3 FP).
Julius Thomas (Jac vs. Ind) – Thomas has been a Colt killer in his three career games against them. He’s scored in all three games (5 TDs) and hasn’t scored fewer than 15.0 FP in any of them.
Martellus Bennett (NE vs. Buf) – Bennett had a big game against the Bills as a Chicago Bear in 2014. He caught 8 of 9 targets for 70 yards and a score good for 21.0 FP.
Rob Gronkowski (NE vs. Buf) – Gronk put up a dud the last time he faced the Bills (2/37) but if we look at his full body of work this has been a great matchup for him over the years. In fact, he has gained more yards and scored more TDs against the Bills than against any other team in the league. He’s got 10 TDs in nine career games in this matchup.
Cam Newton (Car @ Atl) – Can has failed to throw for more than 150 yards in his last three road starts against the Falcons and has only accounted for 5 total TDs in those games (3 passing, 2 rushing). Overall he is averaging 20.4 FPG in those three road games which isn’t terrible but it’s well below his average.
Ben Roethlisberger (Pit vs. KC) – Big Ben last faced the Chiefs back in 2014 and managed only 14.6 FP as he threw it only 25 times for 220 yards and a score. Going back further, Ben hasn’t reached 15 FP in any of his last three in this matchup.
Matt Ryan (Atl vs. Car) – This hasn’t been a particularly great matchup for either QB over the years. Ryan is averaging only 15.5 FP over the last four games in this series and he’s failed to reach 20 FP all four times. He has managed to throw only 2 TD passes combined in those four games.
Eli Manning (NYG @ Min) – Eli has a long, brutal history against the Vikings. He has never thrown for 300 yards or multiple TDs in seven games against them and hasn’t topped 18.0 FP in this matchup in over a decade. He’s thrown a total of 5 career TDs against the Vikings versus 14 INTs, five of which have been returned for TDs.
LeGarrette Blount (NE vs. Buf) – Blount wasn’t much of a factor in either of his two games against the Bills last year as they held him to a combined 18 carries for 60 yards (3.3 YPC) with no TDs (3.8 FPG).
Matt Forte (NYJ vs. Sea) – Forte carried 20 times against Seattle last year as a Bear back in Week 3 but managed just 74 yards (3.7 YPC) and no receptions for a well below-average 7.4 FP.
Allen Robinson (Jac vs. Ind) – Robinson caught only 5 of his 16 total targets in two meetings with the Colts last year for a total of 84 yards and 1 TD. He put up 12.0 FP in the first game and only 7.1 FP in the second.
Stefon Diggs (Min vs. NYG) – Diggs was a non-factor against the Giants in Week 16 of last season. He caught 4 of his 5 targets but for only 19 yards (5.9 FP).
Kenny Britt (LA @ Ari) – Britt hasn’t topped 65 yards or scored in any of his last five games against the Cardinals and has topped 7.0 FP once in that stretch.
Anquan Boldin (Det @ Chi) – Boldin has failed to reach 40 yards of score in either of his last two games against the Bears over the last two years (7.1 FPG).
Dez Bryant (Dal @ SF) – Dez has only faced the 49ers once over the past two seasons back in Week 1 2014 but we’ll note that he only caught 4 passes for 55 yards in that game (9.5 FP).
Sammy Watkins (Buf @ NE) – Watkins is averaging 9.7 FPG in his four career games against the Patriots but that really doesn’t tell the whole story. He’s had one good game (18.0 FP) but in the other three he has failed to catch more than 3 balls, gain more than 60 yards or score (6.9 FPG).
Jason Witten (Dal @ SF) – Witten has only played the 49ers four times in the regular season in his long career and only once in the last five seasons. In that 2014 matchup Witten was held to just 14 yards on 2 catches (even though he was targeted 6 times) for 3.4 FP.
Jacob Tamme (Atl vs. Car) – Tamme averaged 6.8 FPG in two meetings with the Panthers last year. He failed to reach 30 yards or score in both matchups.