San Francisco 49ers C Jake Brendel (hamstring), DE Yetur Gross-Matos (hamstring, knee), DE Bryce Huff (hamstring), CB Deommodore Lenoir (quadriceps), RB Christian McCaffrey (non-injury), WR Ricky Pearsall (knee) and OT Trent Williams (non-injury) did not participate in practice Wednesday, Oct. 22. OT Spencer Burford (knee), LB Luke Gifford (hamstring), CB Renardo Green (toe), QB Brock Purdy (toe) and CB Upton Stout (ankle) were limited during practice. DT Kalia Davis (hand), WR Jauan Jennings (ankle, rib, shoulder), QB Mac Jones (knee, oblique) and DT CJ West (thumb) fully participated in practice.
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